Cannabidiol (CBD) is a type of non-psychoactive cannabinoid sourced from the leaves and flowers of the cannabis plant. CBD is one at least 113 known cannabinoids derived from cannabis. Cannabinoids are a class of natural chemical compounds that interact with cannabinoid receptors in the body in the endocannabinoid system. There are three types of cannabinoids:
· Endocannabinoids: produced naturally by the body, such as 2-Arachidonoylglycerol (2-AG) and Anandamide (the so-called “bliss molecule,” which produces the “runner’s high”)
· Phytocannabinoids: produced naturally by plants, like cannabis
· Synthetic: created artificially, and used clinically in medications, such as Marinol or Dronabinol, and so-called "designer drugs," such as K2, Spice, Black Mamba, and more.
Dustin Sulak, D.O., describes the endocannabinoid system as, “literally a bridge between mind and body.” The interaction of cannabinoids and cannabinoid receptors is analogous to a lock and key mechanism, affecting neurotransmitters, or the chemicals in the body which transmit messages between the brain and various body systems—which influences mood, appetite, sleep, memory, pain and more.
There are two types of cannabinoid receptors:
· CB1: predominantly in the brain, but also in the kidneys, liver, and lungs
· CB2: predominantly in the immune system
Notably, while marijuana’s THC cannabinoid binds to the CB1 receptors in the brain (orthosteric bond), which produces the euphoric effect—or “high”—and a dysphoric effect for some, CBD does not bind directly to CB1 receptors and counteracts the psychoactive effects of THC (allosteric bond). It does so by inhibiting THC's ability to bind, by altering the shape of the receptor, so that THC cannot "fit the lock."
CBD is present in both species of cannabis—hemp and marijuana—but in varying concentrations. Hemp contains higher levels of CBD, with minimal psychoactive THC cannabinoid, whereas marijuana has a lower concentration of CBD and a higher concentration of THC. Thus, CBD with low-to-no THC will confer the maximal therapeutic benefit without the potentially problematic issues posed by THC-containing products.
Innovative extraction and manufacturing methods make it possible to harness the potential of CBD and offer it in a variety of forms, allowing customers to choose the best product for their individual needs and preferences.
What are the different forms of CBD available?
Currently, CBD is extracted and distilled to produce three common forms of CBD:
· CBD isolate: a highly purified form of cannabidiol, which is 99% pure, but lacks all the other plant compounds, such as terpenes (the source of the distinctive smell of cannabis), flavonoids, fatty acids, vitamins, and minerals present in the whole plant, and contains no THC.
· Full-spectrum CBD: contains cannabidiol, and all the other plant compounds, but it also contains trace amounts of THC, which while very small, can still register on drug screening tests.
· Broad-spectrum CBD: also contains cannabidiol and all the other plant compounds like full-spectrum CBD, but without THC.
These different forms of CBD are processed for use in capsules, or as a tincture, powder, nano-emulsion or essential oil and incorporated into other products including foods, gummies, beverages, topical salves and much more.
Why would a customer choose broad-spectrum versus full-spectrum CBD?
Utilizing the whole plant produces the most effective CBD. There are approximately 500 known compounds in the cannabis plant, and when these compounds interact synergistically, they generate what is known as the "entourage effect." Full-spectrum CBD preserves the small trace amounts of THC, and the other non-psychotropic cannabinoids modulate its effects, but it is still detectable on drug tests. For this reason, broad-spectrum CBD, which is THC-free, is typically the most desirable option for customers who want the maximum benefits of the whole-plant approach, but eliminate the problematic THC.
What is the best CBD oil dosage for you?
CBD dosage varies greatly by the individual. A typical daily dosage would range between 5mg to 100mg depending on the severity of ailment the user is treating, and personal preference. Often users will gradually up their intake over time as they become comfortable with taking CBD daily. Our tinctures range from 8.33mg (250mg total)to 33.33mg (1000mg total) per full dropper. If you take one dropper per day, our 1oz tinctures will last one month.